Neurogenic compositions and methods

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61P 25/28 (2006.01) C07K 14/475 (2006.01) C12N 15/10 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2384658

The present invention has found that the Mts1 protein is expressed in white matter astrocytes in the spinal cord. Such expression is significantly increased following sciatic nerve injury or dorsal root injury, particularly in astrocytes surrounding dorsal funiculus containing the central processes of the injured primary sensory neurons. The present invention has further demonstrated that Mts1 proteins administered extracellularly promote neurite outgrowth from neuronal cells. Based on these surprising findings, the present invention provides compositions and methods that are useful for the treatment of various neurological conditions characterized by death, degeneration or injury of neuronal cells.

La présente invention concerne la protéine Mts1, exprimée dans les astrocytes de la substance blanche de la moelle épinière. Ladite expression augmente de façon significative suite à une lésion du nerf grand sciatique ou à une lésion de la racine postérieure, en particulier dans les astrocytes entourant le funiculus dorsal contenant les principaux prolongements des neurones sensitifs primaires atteints. Les protéines Mts1 administrées de façon extracellulaire favorisent une excroissance des neurites des cellules neuronales. La présente invention concerne également des compositions et des méthodes utilisées dans le traitement de divers états neurologiques caractérisés par la mort, la dégénération ou la lésion des cellules neuronales.

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