Bis-indole pyrroles useful as antimicrobials agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/00 (2006.01) A61K 31/401 (2006.01) A61K 31/404 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2552350

Compounds of Formula (I), commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

La présente invention concerne des composés de formule (I), communément mentionnés en tant que bis-indole pyrroles, comprenant des composés d'origine naturelle, isolés, des dérivés synthétiques ou semi-synthétiques de ceux-ci ayant des propriétés antimicrobiennes et des compositions antimicrobiennes qui comprennent un ou plusieurs bis-indole pyrroles et dérivés ou analogues de ceux-ci, ayant des propriétés antimicrobiennes. L'invention a également pour objet des compositions pharmaceutiques comprenant des composés de ce type et des procédés pour traiter des infections bactériennes au moyen desdits composés ou desdites compositions pharmaceutiques.

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