Processes and intermediates in the synthesis of...

Details Processes and intermediates in the synthesis of... Processes and intermediates in the synthesis of...

C - Chemistry, Metallurgy

07

D

C07D 239/10 (2006.01) C07C 69/734 (2006.01) C07C 235/34 (2006.01) C07C 255/37 (2006.01) C07C 259/06 (2006.01) C07C 271/16 (2006.01) C07C 271/20 (2006.01)

Patent

CA 2196309

Disclosed are novel processes for preparing the pharmaceutically active compound 5-(3-[(2S)-exo- bicyclo [2.2.1] kept-2-yloxy]-4-methoxyphenyl)-3, 4, 5, 6- tetrahydropyrimidin-2(1H)-one of the formula: (see formula I) and its corresponding 2R enantiomer and for preparing certain intermediates used in the synthesis of these compounds. Also disclosed are novel intermediates used in the synthesis of such pharmaceutically active compounds and other novel compounds that are related to such intermediates.

L'invention concerne de nouveaux procédés permettant de préparer le composé pharmaceutiquement actif 5-(3-[(2S)-exo-bicyclo[2.2.1]hept-2-yloxy]-4-méthoxyphenyl)-3,4,5,6-tétrahydropyrimidin-2(1H)-one et son énantiomère 2R correspondant, ainsi que de préparer certains intermédiaires utilisés dans la synthèse de tels composés. L'invention concerne également de nouveaux intermédiaires utilisés dans la synthèse de tels composés pharmaceutiquement actifs, ainsi que d'autres nouveaux composés apparentés à de tels intermédiaires.

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