Process for preparing cephalosporins

C - Chemistry – Metallurgy – 12 – P

Patent

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C12P 35/04 (2006.01)

Patent

CA 2094686

X-8505 A S T R A C T The invention relates to an improved process for preparing cephalosporins by reaction compounds such as 7- amino-cephalosporanic acid, 7-amino-3-deacetoxy- cephalosporanic acid or their derivatives with derivatives of .alpha.-amino acids in the presence of a properly immobilized penicillin acylase enzyme under the following conditions, independently, or in combination: (1) at a temperature ranging from 0°C to +20°C; or (2) at ambient pH; with a high molar ratio of .alpha.-amino acid to a cephalosporanic nucleus.

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