Genetic induction of receptors for targeted radiotherapy

Details Genetic induction of receptors for targeted radiotherapy Genetic induction of receptors for targeted radiotherapy

A - Human Necessities

61

K

A61K 51/04 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2234102

The present invention provides a method to achieve radioisotopic localization at tumor sites, i.e., a method of enhancing radiolabeled ligand localization to a tumor in an individual in need of such treatment, comprising the steps of: transducing said tumor with a gene encoding a membrane expressed protein unique to said tumor; and administering to said individual a radiolabeled ligand which specifically binds to said protein. The use of gene therapy technology to induce expression of high affinity membrane molecules/receptors can enhance the specificity of radioisotope localization while the use of radioactive isotopes with the ability to deliver radiation damage across several cell diameters will compensate for less than perfect transduction efficiency.

Cette invention porte sur un procédé visant à permettre un repérage radio-isotope de sites tumoraux, c'est à dire un procédé améliorant le repérage d'un ligand radiomarqué sur une tumeur chez un individu ayant besoin de ce traitement. Le procédé consiste à effectuer une transduction de ladite tumeur à l'aide d'un gène codant une protéine membranaire exprimée, propre à cette tumeur, et à administrer audit individu un ligand radiomarqué se liant de manière spécifique à ladite protéine. Le recours à la technique de thérapie génique pour induire l'expression de molécules/récepteurs membranaires à spécificité élevée peut améliorer la spécificité du repérage radio-isotope tandis que l'emploi d'isotopes radioactifs capables de causer un dommage par rayonnement dans plusieurs diamètres de cellules compense une efficacité de la transduction que l'on ne saurait qualifier de parfaite.

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