Substituted 6,5-hetero-bicyclic derivatives

Details Substituted 6,5-hetero-bicyclic derivatives Substituted 6,5-hetero-bicyclic derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) C07D 471/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2263566

This invention relates to compounds of formula (I), wherein the dashed lines represent optional double bonds; A is nitrogen or CR7; B is -NR1R2, -CR1R2R10- C(=CR2R11)R1, -NHCR1R2R10, -OCR1R2R10, -SCR1R2R10, -CR2R10NHR1, -CR2R10OR1, - CR2R10SR1 or -COR2; J and K are each independently nitrogen or carbon and both J and K are not nitrogens; D and E are each selected, independently, from nitrogen, CR4, C=O, C=S, sulfur, oxygen, CR4R6 and NR8; G is nitrogen or carbon; and their use for the prevention or inhibition of a disorder that can be treated by antagonizing CRF.

L'invention concerne des composés de formule (I), dans laquelle les lignes pointillées représentent des doubles liaisons optionnelles; A est azote ou CR?7¿; B est NR?1¿R?2¿, CR?1¿R?2¿R?10¿-C(=CR?2¿R?11¿)R?1¿, NHCR?1¿R?2¿R?10¿, OCR?1¿R?2¿R?10¿, SCR?1¿R?2¿R?10¿, CR?2¿R?10¿NHR?1¿, CR?2¿R?10¿OR?1¿, CR?2¿R?10¿SR?1¿ ou COR?2¿; J et K sont indépendamment azote ou carbone et ne sont pas en même temps azote; D et E sont choisis indépendamment entre azote, CR?4¿, C=O, C=S, soufre, oxygène, CR?4¿R?6¿ et NR?8¿; G est azote ou carbone. Elle concerne également l'utilisation de ces composés pour prévenir ou inhiber un trouble pouvant être traité par antagonisation de la substance libératrice de la corticostimuline (CRF).

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