A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2251727
Therapeutic compositions, as well as methods for treatment of a disease that is characterized by defective chloride conduction across a cellular membrane, are disclosed. These compositions contain a polypeptide that has one or more of the following characteristics: 1) the ability to spontaneously form a channel in a lipid bilayer, 2) the ability to selectively transport chloride ions across that bilayer, and 3) the ability to dissolve in an aqueous physiological solution. These polypeptides include, but are not limited to, IC1n and porin molecules, such as aerolysin, cryptdin 2 and cryptdin 3.
L'invention porte sur des compositions thérapeutiques et sur des méthodes de traitement d'une maladie caractérisée par un défaut de conduction des chlorures à travers la membrane cellulaire. Lesdites compositions contiennent un polypeptide présentant une ou plusieurs des caractéristiques suivantes: (1) capacité de formation spontanée d'un canal dans une double couche de lipide, (2) capacité de transport sélectif d'ions chlorure à travers cette double couche, et (3) capacité de dissolution dans une solution physiologique aqueux. Ces polypeptides comportent non exclusivement des molécules d'I¿Cln? et de porine, telles que l'aérolysine, la cryptdine 2 et la cryptdine 3.
Lencer Wayne
Madara James
Selsted Michael
Lencer Wayne
Madara James
Selsted Michael
Smart & Biggar
The Brigham And Women's Hospital
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