C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C07K 17/00 (2006.01) C12N 15/10 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2378072
The present invention provides solid supports (e.g., glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprising one or more reactive sites for attachment to solid supports and polymer hydrogels. The invention further provides novel compositions and methods for the preparation of biomolecules, solid supports and polymer hydrogels comprising reactive sites. The invention also provides for preparation of crosslinked solid supports, polymer hydrogels, and hydrogel arrays, wherein one or more biomolecules is attached by means of the reactive sites in a photocycloaddition reaction. Advantageously, according to the invention, crosslinking of the hydrogel and attachment of biomolecules can be done in a single step.
L'invention concerne des supports solides (par exemple, du verre) et des hydrogels polymères (en particulier des matrices d'hydrogels polymères sur un support solide) comprenant un ou plusieurs sites réactifs permettant la fixation de biomolécules ; ainsi que des biomolécules comprenant un ou plusieurs sites réactifs permettant la fixation à des supports solides et à des hydrogels polymères. L'invention concerne également des nouvelles compositions et des nouveaux procédés de préparation de biomolécules, de supports solides et d'hydrogels polymères comprenant des sites réactifs. L'invention concerne également la préparation de matrices d'hydrogels, d'hydrogènes polymères et de supports solides réticulés, une ou plusieurs biomolécules étant fixées au moyen des sites réactifs lors d'une réaction par photocycloaddition. Selon l'invention, la réticulation de l'hydrogel et la fixation des biomolécules peuvent être réalisées, de manière avantageuse, en une seule étape.
Beuhler Allyson
Brush Charles Kimball
Johnson Travis
Lajos Robert Emil
Mcgowen John
Amersham Biosciences Ab
Cassan Maclean
Motorola Inc.
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