Methods and compositions for diagnosing ankylosing...

Details Methods and compositions for diagnosing ankylosing... Methods and compositions for diagnosing ankylosing...

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2626804

The invention provides a method for determining the efficacy of a TNF.alpha. inhibitor, such as a TNF.alpha. antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker.

L'invention porte sur une méthode déterminant l'efficacité d'un inhibiteur du TNF.alpha., tel qu'un anticorps anti TNF.alpha. ou l'un de ses fragments, se fixant à un se fixant à un antigène, pour traiter la spondylarthrite ankylosante à l'aide d'un biomarqueur de dégradation du collagène, ou d'un biomarqueur de la synovite.

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