Methods for cohort selection and longevity studies

Details Methods for cohort selection and longevity studies Methods for cohort selection and longevity studies

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 2/00 (2006.01) C07K 14/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01) G06F 19/00 (2006.01) G06G 7/48 (2006.01) G06G 7/58 (2006.01)

Patent

CA 2485950

This application includes methods and compositions for evaluating a genetic locus associated with longevity and methods for evaluating information from groups of individuals. A longevity-associated locus was identified in gene that encodes for the microsomal triglyceride transfer (MTP) protein on chromosome IV. The polymorphic markers in the region and their methods of use are described. Also disclosed is a method for evaluating information which information for each individual of a first group of individuals and each individual of a second group of individuals is used to select a subset of individuals from the second group. The information can be about a plurality of different biological features. The selection can use a comparison between information for members of the first group and information for members of the subset. It is also possible to compare members of the first group to members of the selected subset with respect to at least one factor. The method can be used to reduce stratification, for example, in the analysis of genetic associations.

L'invention concerne des proc~d~ et des compositions permettant d'~valuer un locus g~n~tique associ~ ~ la long~vit~ et des proc~d~s permettant d'~valuer des informations ~ partir d'un groupe d'individus. Un locus associ~ ~ la long~vit~ a ~t~ identifi~ dans un g­ne codant pour la prot~ine de transfert de triglyc~ride microsomal (MTP) sur un chromosome IV. L'invention concerne ~galement des marqueurs polymorphes de la r~gion et leurs proc~d~s d'utilisation ainsi qu'un proc~d~ d'~valuation d'informations, lesquelles informations sont utilis~es, pour chaque individu d'un premier groupe et pour chaque individu d'un second groupe, pour s~lectionner un sous-ensemble d'individus du second groupe. Lesdites informations peuvent Útre concerner une pluralit~ de caract~ristiques biologiques diff~rentes. La s~lection permet d'utiliser une comparaison entre des informations relatives ~ des membres du premier groupe et des informations relatives ~ des membres du sous-ensemble. Il est ~galement possible de comparer des membres du premier groupe avec des membres du sous-ensemble s~lectionn~ par rapport ~ au moins un facteur. On peut utiliser ce proc~d~ pour r~duire une stratification, par exemple, dans l'analyse d'associations g~n~tiques.

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