Tuberculosis vaccine

Details Tuberculosis vaccine Tuberculosis vaccine

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/04 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12N 15/13 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2165949

The invention relates to a secreted antigens from mycobacteria capable of evoking early (within 4 days) immunological responses from T-helper cells in the form of gamma-interferon release in memory immune animals after rechallenge infection with mycobacteria of the tuberculosis complex. The antigens are present in short term filtrates (ST-CF) from cultured mycobacteria belonging to the tuberculosis complex. One of these antigens, a polypeptide with an apparent molecular weight of 6 kDa, has been identified, and the DNA encoding the polypeptide has been cloned and sequenced. The antigens of the invention are believed useful especially in vaccines, but also in diagnostic compositions. Also disclosed are nucleic acid fragments encoding the antigens as well as methods of immunizing animals/humans and methods of diagnosing tuberculosis.

L'invention concerne des antigènes secrétés par des mycobactéries pouvant provoquer des réactions immunologiques précoces (sous 4 jours) de cellules T auxiliaires sous forme de libération de gamma-interféron dans des animaux témoins immuns après infection de ré-épreuve par des mycobactéries du complexe de la tuberculose. Les antigènes sont présents dans des filtrats à court terme (ST-CF) de mycobactéries cultivées appartenant au complexe de la tuberculose. On a identifé un de ces antigènes, un polypeptide possédant un poids moléculaire apparent de 6 kDa et on a cloné et mis en séquence l'ADN codant le polypeptide. Les antigènes décrits s'avèrent efficaces particulièrement dans des vaccins mais également dans des compositions de diagnostic. L'invention concerne également des fragments d'acide nucléique codant les antigènes, ainsi que des procédés d'immunisation de l'homme et de l'animal et des procédés de diagnostic de la tuberculose.

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