C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/56 (2006.01) G01N 33/86 (2006.01)
Patent
CA 2119761
The invention concerns an in vitro method that is particularly useful for the diagnosis of thromboembolic diseases, such as hereditary or non-heriditary thrombophilia, and to determine the risk for trombosis in connection with pregnancy, taking anti-conception pills, surgery etc. The method is characterized in that the coagulation system in a sample is activated wholly or partly in a manner known per se and incubated with activated Protein C, whereupon a substrate conversion reaction rate like clotting or conversion of a chromogenic substrate is determined. The conversion rate obtained is compared with values obtained for normal plasma samples. If the rate is enhanced, it indicates that the individual from which the sample is derived may suffer from a thromboembolic disease.
L'invention concerne une méthode in vitro qui est particulièrement utile pour le diagnostic des maladies thromboemboliques, comme la thrombophilie héréditaire ou non héréditaire, et pour déterminer le risque de thrombose lié à la grossesse, à l'utilisation des anovulants, à la chirurgie, etc. La méthode est caractérisée par le fait que le système de coagulation présent dans un échantillon est activé entièrement ou partiellement, d'une manière connue en soi, par incubation avec de la protéine C activée; on détermine ensuite la vitesse de conversion du substrat comme la coagulation ou la conversion d'un substrat chromogène. La vitesse de conversion obtenue est comparée avec les valeurs obtenues pour des échantillons de plasma normaux. L'augmentation de la vitesse indique que la personne de qui provient l'échantillon peut être atteinte d'une maladie thromboembolique.
Dahlback Bjorn
Fetherstonhaugh & Co.
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