Compositions and their uses for alleviating pain

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/538 (2006.01) A61K 31/137 (2006.01) A61K 31/4164 (2006.01) A61K 31/4168 (2006.01) A61K 31/4178 (2006.01) A61K 31/498 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2486716

The present invention provides a method for the long-term relief of chronic pain in a subject by activating in the subject an analgesic .alpha.-adrenergic receptor in the absence of .alpha.-2A receptor activation over a period of at least three days, such that relief of chronic pain is maintained in the absence of continued activation of said receptor. The analgesic .alpha.- adrenergic receptor can be, for example, the .alpha.-2B receptor.

L'invention concerne un procédé destiné à soulager à long terme une douleur chronique chez un sujet par activation chez ce sujet d'un récepteur .alpha.-adrénergique analgésique sans activation du récepteur .alpha.-2A sur une période d'au moins trois jours, de sorte que le soulagement de la douleur chronique soit maintenu sans activation continue dudit récepteur. Le récepteur .alpha.-adrénergique analgésique peut être, par exemple, le récepteur .alpha.-2B.

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