New pyridazino[4',5':3,4]pyrrolo-[2,1-a]isoquinolines and...

Details New pyridazino[4',5':3,4]pyrrolo-[2,1-a]isoquinolines and... New pyridazino[4',5':3,4]pyrrolo-[2,1-a]isoquinolines and...

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/50 (2006.01) C07D 491/22 (2006.01)

Patent

CA 2178094

The invention relates to new pyridazino [4',5':3,4]- pyrrolo[2,1-a]isoquinolines of the formula Image (I) and the physiologically acceptable salts thereof with acids and complex-forming agents, wherein X is O, S or NHO and R1, R3, R4, R5, R6, R7, R8 and R9 are defined as in the specification, and pharmaceutical preparations containing these compounds.

L'invention concerne des nouvelles pyridazino[4',5':3,4]pyrrolo-[2,1-a]isoquinoléines nouvelles ayant la formule (I), dans laquelle X désigne O, S ou NHO. Ces nouveaux composés ont de précieuses propriétés thérapeutiques. Ils sont utiles comme agents protecteurs du coeur et du cerveau, comme agents thérapeutiques de processus inflammatoires chroniques, comme agents à action anti-proliférative et comme agents thérapeutiques de la colite ulcéreuse et de la maladie de Crohn.

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