C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 39/21 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2101919
2101919 9214755 PCTABS00015 The present invention relates to HIV Tat proteins and integrin cell surface receptor that specifically recognizes the HIV Tat protein. The integrin is a heterodimer containing an .alpha.v subunit and one or more .beta. subunits, such as .alpha.v.beta.5 derived from human cells and .alpha.v.beta.8 derived from rat cells. The present invention further relates to reactive fragments having sequences corresponding to the binding regions of the HIV Tat protein and the Tat binding integrins. Methods of controlling the binding of the HIV Tat protein to cells expressing such integrins are also provided.
Ruoslahti Erkki I.
Vogel Bruce E.
Wong-Staal Flossie Y.
Gowling Lafleur Henderson Llp
La Jolla Cancer Research Foundation
The Regents Of The University Of California
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