Process (i) for the preparation of powdered medicament

Details Process (i) for the preparation of powdered medicament Process (i) for the preparation of powdered medicament

A - Human Necessities

61

J

167/158, 167/165

A61J 3/02 (2006.01) A61K 9/16 (2006.01) A61K 9/72 (2006.01) B01J 2/00 (2006.01)

Patent

CA 2172053

According to the invention there is provided a method of treatment of a finely divided powdered medicament having a particle size smaller than 10 µm and poor flowing properties to form, in a controlled manner, agglomerates or pellets which are free flowing and which are capable of breaking down to provide the finely divided medicament, comprising the steps of agglomeration of the finely divided powdered medicament by feeding the material to a screw feeder, letting the material pass through the screw feeder thereby obtaining agglomerates, spheronizing the resulting agglomerates in order to obtain agglomerates which are more spherical, more dense and more compact than the agglomerates obtained from the agglomeration process in the screw feeder, and sizing the agglomerates to obtain a uniform size of the final product. According to the invention there is also provided an apparatus for carrying out the method.

Est décrit un procédé de traitement d'un médicament en poudre fine présentant une grosseur particulaire inférieure à 10 µm et des caractéristiques d'écoulement médiocres pour former, de manière contrôlée, des agglomérés ou des pastilles qui s'écoulent librement et qui peuvent se décomposer pour donner le médicament en poudre fine. Ce procédé consiste à agglomérer le médicament en poudre fine en acheminant la matière à un alimentateur à vis, en la faisant passer à travers cet alimentateur pour obtenir des agglomérés, à sphéroniser les agglomérés résultants afin d'obtenir des agglomérés qui sont plus sphériques, plus denses et plus compacts que les agglomérés obtenus par le processus d'agglomération dans l'alimentateur à vis, et à calibrer les agglomérés pour obtenir une taille homogène du produit final. Est également décrit un appareil pour la mise en oeuvre du procédé.

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