Lipoxygenase-inhibiting compounds derived from non-steroidal...

Details Lipoxygenase-inhibiting compounds derived from non-steroidal... Lipoxygenase-inhibiting compounds derived from non-steroidal...

C - Chemistry, Metallurgy

07

C

167/100, 260/467

C07C 275/64 (2006.01) A61K 31/00 (2006.01) C07C 259/06 (2006.01) C07C 271/16 (2006.01) C07C 271/30 (2006.01) C07C 327/56 (2006.01) C07C 333/02 (2006.01) C07C 333/12 (2006.01) C07C 335/12 (2006.01) C07C 335/40 (2006.01) C07D 209/16 (2006.01) C07D 209/28 (2006.01) C07D 307/81 (2006.01)

Patent

CA 2040608

-48- ABSTRACT Compounds of the formula: Image wherein R1 is selected from (1) hydrogen; (2) -NR2R3, -OR2 or -SR2 where R2 and R3 are independently selected from hydrogen, alkyl, aryl and alkylaryl; and (3) optionally substituted C1-C8 alkyl, C2-C8 alkenyl, arylalkyl or cycloalkyl; Y is selected from sulfur and oxygen; n is an integer selected from 0 and 1; M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group; and Z is a residue of a non-steroidal antiinflammatory drug of general form Z-COOH; or a pharmaceutically acceptable salt, ester or prodrug thereof, as well as pharmaceutical compositions containing the above compounds and a method for their use as lipoxygenase inhibitors.

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