Method of treating neurodegenerative diseases

Details Method of treating neurodegenerative diseases Method of treating neurodegenerative diseases

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/27 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2339140

The present invention provides a method of treating a neurodegenerative disease, and in particular Alzheimer's disease, Mild Cognitive Impairment or other objective memory impairment which comprises the co-administration of ARICEPT or other cholinesterase inhibitor or cholenergic angonist and an effective amount of a selective COX-2 inhibitor. Although a wide range of COX- 2 inhibitors may be employed in combination with ARICEPT, there are preferred choices which are specifically set forth herein.

La présente invention concerne une méthode de traitement d'une maladie neurodégénérative, en particulier la maladie d'Alzheimer, de troubles cognitifs légers, ou d'autres troubles objectifs de la mémoire. Cette méthode consiste à coadministrer au patient concerné de l'ARICEPT, ou un autre inhibiteur cholinestérasique ou agoniste cholénergique, avec une dose efficace d'un inhibiteur de COX-2 sélectif. Bien qu'une grande variété d'inhibiteurs de COX-2 puisse être utilisée, nous présentons dans cette invention une sélection d'inhibiteurs préférés.

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