C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2621694
A composition, method for causing uptake in animal cells of double stranded RNA (dsRNA) and reduction of a target mRNA and a use of a mixture for the production of a medicament for the treatment for Tumor Necrosis Factor-alpha (TNF-.alpha.) associated inflammatory condition(s) in an animal subject comprising a polynucleotide delivery-enhancing polypeptide and a dsRNA, wherein the polynucleotide delivery-enhancing polypeptide is amphipathic and comprises nucleic acid binding properties are described.
L'invention concerne une composition, un procédé pour provoquer l'absorption d'ARN double brin (ARNdb) dans des cellules animales et réduire un ARNm cible, ainsi qu'une utilisation d'un mélange pour produire un médicament destiné à traiter un ou plusieurs états inflammatoires associés au facteur de nécrose tumorale alpha (TNF-.alpha.) chez un sujet animal. Ledit mélange comprend un polypeptide activant l'acheminement de polynucléotides et un ARNdb, ce polypeptide étant amphipathique et présentant des propriétés de liaison aux acides nucléiques.
Chen Lishan
Chen Yuching
Cui Kunyuan
Houston Michael E. Jr.
Mayer Sasha J.
Borden Ladner Gervais Llp
Chen Lishan
Chen Yuching
Cui Kunyuan
Houston Michael E. Jr.
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