Immunogenic tumor antigens: nucleic acids and polypeptides...

Details Immunogenic tumor antigens: nucleic acids and polypeptides... Immunogenic tumor antigens: nucleic acids and polypeptides...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2445974

The invention provides human chronic myelocytic leukemia-like proteins (CML protein) and isolated nucleic acid molecules encoding the same. Also provided are antibodies that immunospecifically-bind to CML polypeptides or polynucleotides, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which CML polypeptides, polynucleotides, and antibodies are used in the detection, prevention, and treatment of a broad range of pathological states, and methods of treating malignancy-related disorders by modulating activity or expression of CML proteins.

L'invention concerne des protéines humaines du type CML (leucémie myéloïde chronique) et des molécules isolées d'acide nucléique isolées codant pour lesdites protéines. L'invention concerne également des anticorps qui se lient de façon immunospécifique à des polypeptides ou des polynucléotides CML ou des dérivés, des variants, des mutants ou des fragments desdits anticorps. L'invention concerne en outre des méthodes dans lesquelles les polypeptides, les polynucléotides et les anticorps CML servent à détecter, prévenir et traiter un large éventail d'états pathologiques ainsi que des méthodes qui permettent de traiter des affections associées à des tumeurs malignes par la modulation de l'activité ou de l'expression des protéines du type CML.

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