C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/46 (2006.01) A61K 31/505 (2006.01) A61P 3/06 (2006.01)
Patent
CA 2598869
Substituted 1,1,1-trifluoro-3-[(benzyl)-(pyrimidin-2-yl)-amino]-propan-2-ol compounds, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
L'invention porte sur des composés 1,1,1-trifluoro-3-[(benzyl)-(pyrimidin-2-yl)-amino]-prop an-2-ol substitués, sur des préparations pharmaceutiques les contenant et sur leur utilisation pour augmenter le niveau de certains lipides plasmiques dont les lipoprotéines de cholestérol de haute densité (HDL), et réduire le niveau de certains autres lipides plasmiques tels que le cholestérol LDL et les triglycérides, et en conséquence traiter les maladies exacerbées par de bas niveaux de cholestérol HDL et/ou des niveaux élevés de cholestérol LDL et de triglycérides, telles que l'athérosclérose et les maladies cardio-vasculaires chez certains mammifères dont l'homme.
Chang George
Pence Michael Patrick
Prizer Products Inc.
Sim & Mcburney
LandOfFree
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