Method of reducing the severity of host vs. graft reaction...

Details Method of reducing the severity of host vs. graft reaction... Method of reducing the severity of host vs. graft reaction...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 9/107 (2006.01) A61K 38/10 (2006.01) A61K 38/14 (2006.01) A61P 37/06 (2006.01) G01N 33/554 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2263816

A method for reducing the severity of host vs. graft reaction (HVGR) by the transplant recipient of donor organ or tissue by the transplant recipient and is based on the discovery that hsp60 autoimmunity can function as an accelerator of foreign immunity and the down-regulation of hsp60 autoimmunity suppresses or prevents the graft rejection reaction. Administration of any composition which causes the down-regulation of hsp60 autoimmunity, such as hsp60 or peptide p277 in a tolerogenic carrier or a biologically active carrier capable of mediating a TH1~TH2 shift, will thus reduce the severity of HVGR.

Une méthode de réduction de la gravité de la réaction de l'hôte contre le greffon par le receveur de greffe d'un organe ou d'un tissu de donneur est basée sur la découverte que l'autoimmunité vis-à-vis de la protéine du choc thermique hsp60 peut fonctionner comme accélérateur d'immunité étrangère, et sur le fait que la régulation négative de l'autoimmunité vis-à-vis de hsp60 supprime ou empêche la réaction de rejet du greffon. L'administration de m'importe quelle composition provoquant la régulation négative de l'autoimmunité vis-à-vis de hsp60, telle que hsp60 ou le peptide p277 dans un excipient tolérogénique ou un excipient bioactif capable d'induire un déplacement TH1}TH2 réduit ainsi la gravité de la réaction de l'hôte contre le greffon.

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