Matrix metalloproteinase inhibitors and their therapeutic uses

Details Matrix metalloproteinase inhibitors and their therapeutic uses Matrix metalloproteinase inhibitors and their therapeutic uses

C - Chemistry, Metallurgy

07

D

C07D 307/91 (2006.01) A61K 31/195 (2006.01) A61K 31/275 (2006.01) A61K 31/34 (2006.01) A61K 31/343 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) C07C 311/19 (2006.01) C07C 323/58 (2006.01) C07D 209/88 (2006.01) C07D 333/76 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2256716

The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having Formula (I). More particularly, the present invention relates to a method of treating diseases in which matrix metalloproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.

La présente invention porte sur un procédé d'inhibition de métalloprotéinases matricielles mettant en oeuvre des composés qui sont des dérivés de dibenzofurane sulfonamide ayant la formule (I). L'invention porte plus particulièrement sur un procédé de traitement de pathologies dans lesquelles interviennent les métalloprotéinases matricielles, pathologies telles que sclérose en plaques, rupture de la plaque d'athérosclérose, resténose, anévrisme de l'aorte, insuffisance cardiaque, paradontolyse, ulcération de la cornée, brûlures, ulcères de décubitus, lésions ou ulcères chroniques, métastase cancéreuse, angiogénie tumorale, arthrite ou autre maladies autoimmunes ou inflammatoires selon l'invasion des tissus par les leucocytes.

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