Regimens for intra-articular viscosupplementation

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/728 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2744999

The invention provides viscosupplementation methods for treating osteoarthritis and joint injury with HA-based viscosupplements, particularly viscosupplements with an intra-articular residence half-life shorter than 3 weeks. Viscosupplements for use in the methods of the invention may be further characterized in that they contain less than 20 mg/ml HA, at least 5% (w/w) of which is in a gel form, such as, e.g., hylan B. In an illustrative embodiment, hylan G-F 20 (Synvisc® ) is administered in a single intra-articular knee injection of 6~ 2 ml.

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