Targeting lipids

Details Targeting lipids Targeting lipids

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2708173

The present invention provides targeting lipids of structure (Cl) L100 - linker - L101 where L100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, L101 is a ligand or - CH2CH2(OCH2CH2)p O(CH2)q CH2- ligand, p is 1-1000, and q is 1-20. In addition, the invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic aicd to cellsin vivo.

L'invention concerne des lipides de ciblage de structure (Cl) L100 - lieur - L101, dans laquelle L100 est lipide, lipophile, alkyle, alcényle ou alkynyle; L101 est un ligand ou -CH2CH2(OCH2CH2)pO(CH2)qCH2-ligand; p est 1-1000, et q est 1-20. L'invention concerne également des compositions et des méthodes d'administration d'agents thérapeutiques à des cellules. Ces compositions comprennent en particulier de nouveaux lipides et des particules d'acide nucléique-lipide qui assurent une encapsulation efficace d'acides nucléiques et une administration efficace d'acides nucléiques encapsulés à des cellules, in vivo.

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