Modulation of gene expression by oligomers targeted to...

Details Modulation of gene expression by oligomers targeted to... Modulation of gene expression by oligomers targeted to...

C - Chemistry, Metallurgy

12

N

C12N 15/67 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07K 14/72 (2006.01) C12N 9/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2629664

Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.

Selon l~invention, la synthèse d~une transcription cible d~un gène est sélectivement accrue dans une cellule mammalienne par la mise en contact de la cellule avec un oligomère polynucléotide de 12 à 28 bases complémentaire à une région d~un promoteur cible du gène dans des conditions permettant à l~oligomère d~accroître sélectivement la synthèse de la transcription cible.

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