Thienoimidazole derivatives, their production and use

Details Thienoimidazole derivatives, their production and use Thienoimidazole derivatives, their production and use

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2054465

Abstract of the Disclosure Benzimidazole derivatives of the formula (I): Image (I) wherein the ring A is a thiophene ring which may optionally contain substitution in addition to the R3 group; R1 is hydrogen or optionally substituted hydrocarbon residue which may be bonded through a hetero atom; R2 and R3 are independently a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2; or a salt thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.

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