Vegf antagonist formulations suitable for intravitreal...

Details Vegf antagonist formulations suitable for intravitreal... Vegf antagonist formulations suitable for intravitreal...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/19 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2654510

Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic formulations include a stable liquid formulation and a lyophilizable formulation. Preferably, the protein antagonist has the amino acid sequence shown in SEQ ID NO:4.

La présente invention concerne des formulations ophtalmiques d'une protéine de fusion antagoniste spécifique du facteur de croissance endothélial vasculaire (VEGF), appropriées à une administration intravitréenne dans l'AEil. Les formulations ophtalmiques contiennent une formulation liquide stable et une formulation lyophilisable. De préférence, la protéine antagoniste comporte la séquence d'acides aminés présentée dans la séquence SEQ ID NO : 4.

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