Process for preparing highly functionalized y-butyrolactams...

Details Process for preparing highly functionalized y-butyrolactams... Process for preparing highly functionalized y-butyrolactams...

C - Chemistry, Metallurgy

07

C

C07C 227/22 (2006.01) C07C 229/08 (2006.01)

Patent

CA 2483830

The invention relates to a process for preparing highly functionalized .gamma.- butyrolactams and .gamma.-amino acids by reductive amination of mucohalic acid or its derivatives, and discloses a process for preparing pregabalin or 3- aminomethyl-5-methyl octanoic acid, GABA analogs with desirable medicinal activity. (Formula I).

L'invention concerne un procédé de préparation d'acides aminés de type y et de y-butyrolactames très fonctionnalisés par le biais d'une animation réductrice d'acide mucohalique ou de ses dérivés. Ladite invention a également trait à un procédé de préparation de prégabalin ou d'acide 3-aminométhyl-5-méthyloctanoïque, d'analogues GABA avec une activité médicinale souhaitable. (Formule I).

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