Substituted phenylalkanoic acid derivatives and use thereof

Details Substituted phenylalkanoic acid derivatives and use thereof Substituted phenylalkanoic acid derivatives and use thereof

C - Chemistry, Metallurgy

07

C

C07C 69/734 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/235 (2006.01) A61K 31/255 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/421 (2006.01) A61K 31/428 (2006.01) A61K 31/4353 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/47 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07C 59/62 (2006.01) C07C 59/68 (2006.01) C07C 59/72 (2006.01) C07C 205/56 (

Patent

CA 2477208

A compound represented by the formula (I) or a salt thereof: (see formula I) wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R1(CH2)k- (wherein k represents 0 or an integer of 1 to 3; R1 represents a saturated cyclic alkyl group having 3 to 7 carbon atoms or a saturated condensed cyclic alkyl group having 6 to 8 carbon atoms, and the group R1 may be substituted with a lower alkyl group having 1 to 4 carbon atoms) and the like, and Ar represents a condensed bicyclic group such as naphthalen-1-yl group, which has suppressing action on prostaglandin and leukotriene production and is useful for prophylactic and/or therapeutic treatment of various inflammatory diseases and the like caused by these lipid mediators.

L'invention porte sur un composé représenté par la formule générale (I) [dans laquelle n est un nombre entier compris entre 1 et 3 ; R représente alkyle C3-8, un groupe représenté par R1(CH2)k- (k est un nombre entier compris entre 0 et 3 ; et R1 représente cycloalkyle C3-7 saturé ou alkyle saturé à noyau condensé C6-8, à condition que R1 puisse être substitué par alkyle C1-4), etc. ; et Ar représente un groupe bicyclique à noyau condensé tel que naphatalène-1-yl], ou sur un sel de ce composé. Le composé ou son sel a une activité inhibitrice de la production de prostaglandines et de leucotriènes. Il est notamment utile dans la prévention et les traitements de diverses maladies inflammatoires imputables au médiateur lipidique.

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