A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2656224
The present invention relates to methods of treatment, prevention, management or amelioration of one or more symptoms of diseases or disorders associated with CD20 expression that encompass administration of a combination of (a) one or more antibodies that specifically bind Fc.gamma.RIIB, particularly human Fc.gamma.RIIB, with greater affinity than said antibodies bind Fc.gamma.RIIA, and (b) one or more antibodies that specifically bind to CD20. Such methods include methods of treating, preventing, managing or ameliorating one or more symptoms of a B cell related disease or disorder or an inflammatory disorder. The invention also provides pharmaceutical compositions comprising an anti-Fc.gamma.RIIB antibody and an anti-CD20 antibody.
La présente invention concerne des procédés de traitement, de prévention, de gestion ou d'amélioration d'un ou plusieurs symptômes de maladies ou de troubles associés à l'expression de la CD20. Lesdits procédés comprennent l'administration d'une combinaison de (a) un ou plusieurs anticorps qui se lient spécifiquement au Fc.gamma.RIIB, en particulier au Fc.gamma.RIIB humain, avec une affinité plus grande que celle avec laquelle lesdits anticorps se lient au Fc.gamma.RIIA, et (b) un ou plusieurs anticorps qui se lient spécifiquement à la CD20. Lesdits procédés incluent des procédés de traitement, de prévention, de gestion ou d'amélioration d'un ou plusieurs symptômes d'une maladie ou d'un trouble lié aux cellules B ou d'un trouble inflammatoire. L'invention concerne également des compositions pharmaceutiques comprenant un anticorps anti-Fc.gamma.RIIB et un anticorps anti-CD20.
Rankin Christopher
Tuaillon Nadine
Macrogenics Inc.
Osler Hoskin & Harcourt Llp
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