C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/36 (2006.01)
Patent
CA 2492201
A process for manufacturing a hydroxylated isoflavone of the formula (I) given in the description comprises reacting an appropriately substituted 2- hydroxydeoxybenzoin of the formula (II), also given in the description, with a formic acid anhydride of the formula HCOOCOR3, wherein R3 signifies C2-20- alkyl or various other groups as given in the description, in the presence of a base or in a solvent which acts as a base, and if necessary promoting the ensuing hydrolysis of the so-produced acylated form of the hydroxylated isoflavone of the formula I by acidification. Of particular interest as products of this process are the 5,7~dihydroxyisoflavones, e.g. genistein (5,7,4'-trihydroxyisoflavone).Isoflavones display many useful biochemical effects.
L'invention concerne un procédé de fabrication d'un isoflavone hydroxylé de formule (I). Ledit procédé consiste à faire réagir 2-hydroxydeoxybenzoïne substitué de façon appropriée de formule (II) avec un anhydride d'acide formique de formule HCOOCOR?3¿, dans laquelle R?3¿ représente C¿2-20?-alkyle ou d'autres groupes divers en présence d'une base ou dans un solvant qui agit comme une base, et si nécessaire à promouvoir l'hydrolyse consécutive de la forme acylée ainsi produite de l'isoflavone hydroxylée de formule I par acidification. 5,7-dihydroxyisoflavones, par exemple, génistéine (5,7,4'-trihydroxyisoflavone) sont des produits de ce processus ayant un intérêt particulier. Les isoflavones présentent plusieurs effets biochimiques utiles.
Burdet Bruno
Ruettimann August
Dsm Ip Assets B.v.
Smart & Biggar
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