Imidazopyridine derivatives as 5-ht4 receptor antagonists

Details Imidazopyridine derivatives as 5-ht4 receptor antagonists Imidazopyridine derivatives as 5-ht4 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2146928

Compounds of formula (1), and pharmaceutically acceptable salts thereof, and the use of a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or C1-6 alkyl; R2 is hydrogen or halo; Y is O or NH; Z is of sub-formula (i), (ii), (iii), (iv) or (v), or wherein the piperidine ring in (i) or (ii) is replaced by pyrrolidinyl and/or the N-sub- stituent in (i) or (ii) is replaced by R3 wherein R3 is hydrogen or C1-12alkyl, aralkyl or R3 is (CH2)r-R10 wherein r is 2 or 3 and R10 is selected from cyano, hydroxyl, C1-6 alkoxy, phenoxy, C(O)C1-6alkyl, COC6H5, -CONR11R12, NR11COR12, SO2NR11R12 or NR11SO2R12 wherein R11 and R12 are hydrogen or C1-6 alkyl; or a compound of formula (1) wherein the CO-Y linkage is replaced by a heterocyclic bioisostere; having 5-HT4 receptor antagonist activity.

Affiliated with

Also associated with

Rating

Imidazopyridine derivatives as 5-ht4 receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazopyridine derivatives as 5-ht4 receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazopyridine derivatives as 5-ht4 receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1369493