Self-preserved aqueous pharmaceutical compositions

Details Self-preserved aqueous pharmaceutical compositions Self-preserved aqueous pharmaceutical compositions

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/00 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2663817

The use of a borate/polyol and zinc system to enhance the antimicrobial activity of multi-dose pharmaceutical compositions is described. The compositions do not require a conventional anti-microbial preservative and therefore are referred to as being 'self-preserved'. The compositions possess sufficient antimicrobial activity to satisfy the preservative efficacy requirements of the USP for aqueous ophthalmic compositions.

La présente invention concerne l'utilisation d'un système à base de borate/polyol et de zinc pour augmenter l'activité antimicrobienne de compositions pharmaceutiques à doses multiples. Les compositions ne requièrent pas d'agent de conservation antimicrobien ordinaire et elles sont par conséquent qualifiées de compositions <= à conservation spontanée >=. Les compositions présentent une activité antimicrobienne suffisante pour satisfaire aux exigences d'efficacité de conservation USP concernant les compositions ophtalmiques aqueuses.

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