Therapeutic uses for ip3 receptor-mediated calcium channel...

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A61K 31/00 (2006.01) A61K 31/537 (2006.01) A61K 31/69 (2006.01) A61K 39/10 (2006.01) A61K 45/06 (2006.01) A61P 3/00 (2006.01) A61P 3/12 (2006.01) A61P 9/02 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 31/20 (2006.01) A61P 31/22 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2

Patent

CA 2427757

The use of an IP3 receptor-mediated calcium channel blocker for treating a variety of diseases is herein described. Specifically, the IP3 receptor- mediated calcium channel blocker prevents activation of the transcription factor NF-kB. As a consequence, the IP3 receptor-mediated calcium channel blocker is used as a treatment for diseases and disorders requiring NF-kB activation, for example, inflammatory diseases, some viral infections and some unregulated growth disorders.

L'invention concerne l'utilisation d'un inhibiteur des canaux calciques induit par le récepteur IP¿3? dans le traitement de diverses maladies. Plus particulièrement, l'inhibiteur de canaux calciques induit par le récepteur IP¿3? empêche l'activation du facteur de transcription NF-kB. En conséquence, cet inhibiteur est utilisé en tant que traitement contre les maladies et les troubles nécessitant une activation NF-kB, par exemple, des maladies inflammatoires, certaines infections virales et troubles non régulés du développement.

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