Enhancement of glutathione levels with glutamine

Details Enhancement of glutathione levels with glutamine Enhancement of glutathione levels with glutamine

A - Human Necessities

61

K

A61K 31/195 (2006.01)

Patent

CA 2091766

A method of maintaining and/or enhancing tissue or plasma levels of glutathione is provided. Treatment of a mammal with a supranormal amount of glutamine, or a glutamine equivalent, prevents thereduction in tissue glutathione levels associated with exposure of the mammal to a compound capable of oxidative injury to the tissue. Such compounds may be drugs such as chemotherapeutic agents.Administration of a supranormal amount of glutamine or a glutamine equivalent after exposure of a mammal to a compound capable of oxidative injury to the tissue can ameliorate or prevent injury. Treatment of a mammal with glutamine or a glutamine equivalent can also reduce or prevent starvation -or radiation- associated oxidative damage in the tis- sues.

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