Human secreted proteins

Details Human secreted proteins Human secreted proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2441755

The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating hematopoietic and hematologic diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

La présente invention concerne des polypeptides sécrétés humains et des molécules d'acides nucléiques codant pour ces polypeptides, lesquels sont utiles pour diagnostiquer et traiter des maladies hématopoïétiques et hématologiques ainsi que des troubles et/ou des états pathologiques associés. La présente invention concerne également des anticorps se liant à ces polypeptides. Elle concerne en outre des vecteurs, des cellules hôtes ainsi que des méthodes de recombinaison et des méthodes synthétiques destinées à produire ces polynucléotides, ces polypeptides et/ou ces anticorps. Par ailleurs, l'invention porte sur des méthodes de criblage destinées à identifier des agonistes et des antagonistes des polynucléotides et des polypeptides susmentionnés. Elle se rapporte enfin à des méthodes et à des compositions destinées à inhiber ou accroître la production et la fonction de ces polypeptides.

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