A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A01N 43/00 (2006.01) A01P 1/00 (2006.01) A61K 31/4709 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2681208
A means for decreasing bacterial virulence in a mammal including man or in a plant by inhibition of the Type III secretion system at concentrations that do not prevent or substantially reduce bacterial growth comprises an N-substituted 7-quinolylmethyl amine, in particular one that is further substituted in 5- and 8-position on the quinoline ring. A corresponding therapeutic method and a pharmaceutical composition are also disclosed.
L'invention concerne des moyens pour diminuer la virulence bactérienne ou dans un végétal ou chez un mammifère, dont l'homme, par inhibition du système de sécrétion de type III à des concentrations qui n'empêchent pas ou ne réduisent sensiblement pas la croissance bactérienne et qui incluent une 7-quinolylméthylamine N-substituée, en particulier une 7-quinolylméthylamine N-substituée qui est substituée à nouveau en position 5 et en position 8 sur le cycle de quinoline. Un procédé thérapeutique correspondant et une composition pharmaceutique sont également décrits.
Elofsson Mikael
Creative Antibiotics Sweden Ab
Innate Pharmaceuticals Ab
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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