A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 37/00 (2006.01) A61F 2/00 (2006.01) A61K 39/00 (2006.01) A61M 31/00 (2006.01)
Patent
CA 2596075
The present invention provides methods and devices for reducing the coating variability of a transdermal microprojection delivery device (10). The device has one or more stratum corneum-piercing microproje.sigma.tions (12), wherein each microprojection has a maximum width (Wm) located in the range of approximately 25 % to 75 % of the length (1) of the microprojection and wherein the microprojection has a minimum width proximal to the maximum width. Preferably, the microprojection has a coating of a biologically active agent that at a minimum extends to at least approximately 75 % of the distance from the distal tip to a location corresponding to the maximum width and at most extends up to approximately 90 % of the length of the microprojection.
L'invention concerne des procédés et des dispositifs pour réduire la variabilité d'un revêtement d'un dispositif d'administration par microprojection transdermique. Le dispositif présente une ou plusieurs microprojections perçant la couche cornée, chacune présentant une largeur maximale comprise entre 25 et 75 % de la longueur de la microprojection et une largeur minimale proximale par rapport à la largeur maximale. De préférence, la microprojection présente un revêtement comprenant une substance bioactive qui s'étend au minimum sur au moins 75 % de la distance entre la pointe distale et un emplacement correspondant à la largeur maximale et s'étend au maximum sur 90 % de la longueur de la microprojection.
Ameri Mahmoud
Cormier Michel J. N.
Alza Corporation
Borden Ladner Gervais Llp
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