Adenosine derivatives as a2a receptor agonists

Details Adenosine derivatives as a2a receptor agonists Adenosine derivatives as a2a receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 473/00 (2006.01) A61K 31/495 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2662104

A compound of formula (I), or stereoisomers or pharmaceutically acceptable salts thereof, formula (1), or stereoisomers or pharmaceutically acceptable salts thereof, wherein A, U1, U2, R1a, R1b, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

La présente invention concerne un composé de formule (I), ou des stéréo-isomères ou des sels pharmaceutiquement acceptables de ce dernier. Dans ladite formule, A, U1, U2, R1a, R1b, R2 et R3 sont tels que définis dans la description. Lesdits composés sont utiles pour traiter des troubles induits par l'activation du récepteur de l'adénosine A2A, en particulier des maladies inflammatoires ou obstructives des voies aériennes. L'invention a également trait à des compositions pharmaceutiques qui contiennent les composés selon l'invention, et à un procédé de préparation desdits composés.

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