Streptococcus uberis lactoferrin-binding protein

Details Streptococcus uberis lactoferrin-binding protein Streptococcus uberis lactoferrin-binding protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/09 (2006.01) A61K 39/116 (2006.01) A61K 39/385 (2006.01) C07K 14/00 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2270404

The bovine lactoferrin (bLF) binding protein of Streptococcus uberis (S. uberis) is described, as well as the gene encoding the bLF (1bp). LF-binding proteins can be used in vaccine compositions for the prevention and treatment of S. uberis infections, particularly mastitis, as well as in diagnostic methods for determining the presence of S. uberis infections. Also disclosed is a regulatory region adjacent to 1bp, termed mga.

Cette invention a trait à la protéine de fixation de la lactoferrine bovine (bLF) issue de Streptococcus uberis (S. Uberis) ainsi qu'au gène codant ladite bLF (lbp). On peut utiliser ces protéines de fixation de la lactoferrine dans des compositions vaccinales pour la prévention et le traitement d'infections dues à S. Uberis, des mammites notamment, ainsi que dans le cadre de méthodes diagnostiques visant à déterminer la présence d'infections dues à S. Uberis. L'invention a également trait à une région de régulation adjacente de lbp, dénommée mga.

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