Compound, medicament, vaccine composition and nanocapsules

Details Compound, medicament, vaccine composition and nanocapsules Compound, medicament, vaccine composition and nanocapsules

A - Human Necessities

61

K

A61K 47/36 (2006.01) A61K 9/16 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2745330

The present invention relates to a compound comprising a polyelectrolyte and, covalently linked thereto, an immunological adjuvant and/ or cell targeting ligand, wherein the covalently linked entity can have both adjuvant and cell targeting characteristics. The compound is used in the preparation of hydrophilic vaccine nanoparticles, which preferably have an antigenic compound or therapeutic agent, or genetic information encoding such compounds or agents entrapped in their matrix, or covalently linked to their surfaces. Vaccine compositions comprising the particles of the invention are advantageous, because a strong and long-lasting immune response is obtained following administration of a single dose. In a preferred embodiment, the polyelectrolyte of the compound is an anionic polymer, and the particle comprises a matrix comprising chitosan.

La présente invention concerne un composé comprenant un polyélectrolyte, et un adjuvant immunologique et/ou un ligand de ciblage cellulaire liés de façon covalente au polyélectrolyte, l'entité liée de façon covalente pouvant présenter des caractéristiques dadjuvant et de ciblage cellulaire. Ce composé est utilisé dans la préparation de nanoparticules hydrophiles de vaccin, qui comprennent de préférence un composé antigénique ou un agent thérapeutique, ou des informations génétiques codant pour de tels composés, ou des agents piégés dans leur matrice ou liés de façon covalente à leurs surfaces. Les compositions vaccinales comprenant les particules de l'invention sont avantageuses, car une réponse immunitaire forte et durable est obtenue après ladministration d'une dose unique. Dans un mode de réalisation préféré, le polyélectrolyte du composé est un polymère anionique, et les particules comprennent une matrice contenant du chitosane.

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