C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/04 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2319710
This invention relates to oligonucleotides complementary to the thioredoxin and thioredoxin reductase genes which modulate tumor cell growth in mammals. This invention is also related to methods of using such compounds in inhibiting the growth of tumor cells in mammals. This invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.
L'invention concerne des oligonucléotides complémentaires des gènes de thiorédoxine et de thiorédoxine transférase, qui modulent la croissance de cellules tumorales chez les mammifères. Elle porte aussi sur des procédés d'utilisation desdits composés dans l'inhibition de la croissance de cellules tumorales chez les mammifères ainsi que sur des compositions comprenant un excipient acceptable du point de vue pharmaceutique et une dose efficace d'un composé de l'invention.
Lee Yoon S.
Wright Jim A.
Young Aiping H.
Genesense Technologies Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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