Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase...

Details Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase... Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 33/00 (2006.01)

Patent

CA 2636701

The present invention relates to pyrrolo[3,2-c]pyridine-4-one 2-indolinone compounds of Formula (I) and their pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8 X , Y and ~. have the meaning cited in the specification. Also disclosed are the pharmaceutical compositions containing the foregoing compounds, methods for the preparation and pharmaceutical use thereof, particularly as protein kinase inhibitors. Formula (I).

L'invention concerne des composés de pyrrolo[3,2-c]pyridine-4-one 2-indolinone représentés par la formule (I) et les sels pharmaceutiquement acceptables de ceux-ci. Dans la formule, R1, R2, R3, R4, R5, R6, R7, R8, X, Y et ~ ont les notations mentionnées dans la description. L'invention concerne aussi des compositions pharmaceutiques contenant ces composés, des procédés de préparation et d'utilisation pharmaceutique de ceux-ci, en particulier comme inhibiteurs de protéines kinases.

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