Selective subtype alpha 2 adrenergic agents and methods for...

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A61K 31/415 (2006.01) A61P 1/04 (2006.01) A61P 1/12 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/02 (2006.01) A61P 19/02 (2006.01) A61P 25/14 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2724435

The invention provides methods for treating disorders associated with selective subtype modulation of alpha 2 adrenergic receptors. In particular, the invention provides methods employing well-defined N-[1-(2 and/or 3-substituted-phenyl) -alkyl]-(4,5-dihydro-1H-imidazol-2-yl)-amines and pharmaceutical compositions thereof to treat disorders associated with selective subtype alpha 2 adrenergic receptor modulation, such as ocular disorders, pain and central nervous system (CNS) motor disorders.

La présente invention concerne des méthodes de traitement de troubles associés à la modulation sélective des récepteurs alpha 2 adrénergiques. L'invention concerne, en particulier, des méthodes utilisant des N-[1-[phényle substitué en position 2 et/ou 3]-alkyl]-(4,5-dihydro-1H-imidazol-2-yl)-amines bien définies et des compositions pharmaceutiques en contenant, en vue du traitement de troubles associés à la modulation sélective des récepteurs alpha 2 adrénergiques.

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