Vitamin d analog - nel, methods and uses thereof

Details Vitamin d analog - nel, methods and uses thereof Vitamin d analog - nel, methods and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61P 13/12 (2006.01) A61P 17/06 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2637817

Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms; straight or branched chain alkenyl groups having from 2 to 8 carbon atoms; straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms; straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.

L'invention concerne des composés de formule (IA) ou (IB), dans laquelle X1, X2 et X3 sont indépendamment sélectionnés dans le groupe constitué par H ou des groupes de protection hydroxy; et R1 est choisi parmi des groupes alkyle à chaîne droite ou ramifiée comportant entre 1 et 8 atomes de carbone, des groupes alcényle à chaîne droite ou ramifiée comportant entre 2 et 8 atomes de carbone, des groupes alkyle substitués par hydroxy à chaîne droite ou ramifiée comportant entre 1 et 8 atomes de carbone, des groupes alcényle substitués par hydroxy à chaîne droite ou ramifiée comportant entre 2 et 8 atomes de carbone. Ces composés sont utilisés dans la préparation de compositions pharmaceutiques et sont utiles pour le traitement de diverses affections biologiques.

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