C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6561 (2006.01) A61K 39/39 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2741291
The compounds of the subject invention are adjuvant molecules that comprise an imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-.alpha., IL-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens
La présente invention concerne des composés qui sont des molécules adjuvantes qui comprennent une molécule dimidazoquinoléine liée de manière covalente à un groupe phospho- ou phosphonolipide. Les composés de linvention se sont avérés être des inducteurs de linterféron-a, de lIL-12 et dautres cytokines immunostimulantes et possèdent un profil dactivité amélioré comparé à des inducteurs des cytokines connus lorsquils sont utilisés en tant quadjuvants pour des antigènes vaccinaux.
Glaxosmithkline Biologicals Sa
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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