Gpr7-selective ligand and use thereof

Details Gpr7-selective ligand and use thereof Gpr7-selective ligand and use thereof

C - Chemistry, Metallurgy

07

K

C07K 7/02 (2006.01) A61K 38/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 5/06 (2006.01) A61P 25/06 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 29/00 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2587398

A compound represented by Trp-Tyr-Lys-(X)n-Gly-Arg-Ala~Ala-Gly-Leu-Leu-Ser-Gly- Leu-NH2 or a pharmaceutically acceptable salt thereof is a GPR7-selective ligand. [In the formula, n is an integer of 2-10; and X's each independently represents -NH-(CH2)m-CO- (wherein m is an integer of 2-6), the group represented by the formula (1) (wherein l is 0 or 1) which may be substituted, etc.]

L'invention a pour objet un ligand GPR7-sélectif, qui peut être soit un composé représenté par Trp-Tyr-Lys-(X)n-Gly-Arg-Ala­Ala-Gly-Leu-Leu-Ser-Gly-Leu-NH2, soit un sel de qualité pharmaceutique de ce composé. [Dans la formule, n est un entier compris entre 2 et 10 ; et les groupements X représentent chacun -NH-(CH2)m-CO- (où m est un entier compris entre 2 et 6), les groupements représentés par la formule (1) (où l est égal à 0 ou à 1) pouvant être substitués, etc.]

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