C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01) C07K 1/18 (2006.01)
Patent
CA 2088164
2088164 9202554 PCTABS00010 Three mammalian nuclear phosphoproteins (32KD, 35KD and 42KD) are disclosed which are useful in the diagnosis and prognosis of tumors of lymphoid and epithelial origin. The three proteins are immunologically related to each other. The level of expression of the proteins correlates with the malignant potential of lymphoid and epithelial tumors. In addition, in some cases the subcellular location of the proteins is indicative of malignant potential. Antibodies reactive with the proteins are disclosed as diagnostic tools, as are nucleic acid probes and primers for quantitating the messenger RNAs encoding the proteins. Methods for preparing and purifying the proteins are also taught.
Johns Hopkins University
Sim & Mcburney
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