Formulations decreasing particle exhalation

Details Formulations decreasing particle exhalation Formulations decreasing particle exhalation

A - Human Necessities

61

K

A61K 47/02 (2006.01)

Patent

CA 2558426

Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

L'invention porte sur des préparations d'administration pulmonaire développées pour traiter ou réduire certaines infectiosités ou maladies telles que les infections virales en particulier la tuberculose, le SRAS, la grippe, le syndrome syncytial respiratoire de l'homme, et la fièvre aphteuse de l'animal, et pour réduire les symptômes d'allergies et d'autres maladies pulmonaires. Lesdites préparations comportent une substance qui modifie significativement les propriétés physiques telles que la tension superficielle et l'élasticité superficielle du mucus tapissant les poumons, substance qui peut être saline et isotonique, ou facultativement consister en un support. Une telle préparation peut s'administrer sous forme de solution liquide, de suspension, d'aérosol, ou de poudre dont les particules sont principalement des solutés agissant par osmose. On peut facultativement ajouter à la préparation des médicaments tels que des antiviraux ou des antibiotiques, coadministrables ou intégrés.

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